Exposure to arsenic at different life-stages and DNA methylation meta-analysis in buccal cells and leukocytes.

ABSTRACT:

Background

Arsenic (As) exposure through drinking water is a global public health concern. Epigenetic dysregulation including changes in DNA methylation (DNAm), may be involved in arsenic toxicity. Epigenome-wide association studies (EWAS) of arsenic exposure have been restricted to single populations and comparison across EWAS has been limited by methodological differences. Leveraging data from epidemiological studies conducted in Chile and Bangladesh, we use a harmonized data processing and analysis pipeline and meta-analysis to combine results from four EWAS.

Methods

DNAm was measured among adults in Chile with and without prenatal and early-life As exposure in PBMCs and buccal cells (N = 40, 850K array) and among men in Bangladesh with high and low As exposure in PBMCs (

SUBMITTER: Bozack AK 

PROVIDER: S-EPMC8272372 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature