Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell.

ABSTRACT:

Background

Skin aging is the most common dermatological problem caused by intrinsic and extrinsic factor, such as exposure to (ultraviolet) UV rays. Chlorogenic acid (CA) is a phenolic compound which is known for its antioxidant properties against oxidative stress.

Objective

This study investigates the antiaging and anti-inflammatory properties of CA on UV-induced skin fibroblast cells.

Methods

Anti-inflammatory properties of CA were assessed by measuring inflammatory-related proteins IL-1β and TNF-α, while antiaging properties of CA were assessed by measuring reactive oxygen species (ROS), apoptosis, live and necrotic cells, and COL-3 gene expression level.

Results

Treating UV-induced skin fibroblast cells with CA decreased the level of ROS, IL-1β, TNF-α, apop

SUBMITTER: Girsang E 

PROVIDER: S-EPMC8272460 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature