Construction and validation of a 15-gene ferroptosis signature in lung adenocarcinoma.

ABSTRACT:

Background

Ferroptosis is a novel form of programmed cell death characterized by the excessive accumulation of intracellular iron and an increase in reactive oxygen species. Emerging studies have shown that ferroptosis plays a vital role in the progression of lung adenocarcinoma, but the effect of ferroptosis-related genes on prognosis has been poorly studied. The purpose of this study was to explore the prognostic value of ferroptosis-related genes.

Methods

Lung adenocarcinoma samples were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. The least absolute shrinkage and selection operator (LASSO) Cox regression algorithm was used to establish a predictive signature for risk stratification. Kaplan-Meier (K-M) survival analysis and r

SUBMITTER: Tu G 

PROVIDER: S-EPMC8272465 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature