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Sensor array and gas chromatographic detection of the blood serum volatolomic signature of COVID-19.

ABSTRACT: Volatolomics is gaining consideration as a viable approach to diagnose several diseases, and it also shows promising results to discriminate COVID-19 patients via breath analysis. This paper extends the study of the relationship between volatile compounds (VOCs) and COVID-19 to blood serum. Blood samples were collected from subjects recruited at the emergency department of a large public hospital. The VOCs were analyzed with a gas chromatography mass spectrometer (GC/MS). GC/MS data show that in more than 100 different VOCs, the pattern of abundances of 17 compounds identifies COVID-19 from non-COVID with an accuracy of 89% (sensitivity 94% and specificity 83%). GC/MS analysis was complemented by an array of gas sensors whose data achieved an accuracy of 89% (sensitivity 94% and specificity 80%).

SUBMITTER: Mougang YK

PROVIDER: S-EPMC8272622 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Sensor array and gas chromatographic detection of the blood serum volatolomic signature of COVID-19.

Mougang Yolande Ketchanji YK Di Zazzo Lorena L Minieri Marilena M Capuano Rosamaria R Catini Alexandro A Legramante Jacopo Maria JM Paolesse Roberto R Bernardini Sergio S Di Natale Corrado C

iScience 20210710 8

Volatolomics is gaining consideration as a viable approach to diagnose several diseases, and it also shows promising results to discriminate COVID-19 patients via breath analysis. This paper extends the study of the relationship between volatile compounds (VOCs) and COVID-19 to blood serum. Blood samples were collected from subjects recruited at the emergency department of a large public hospital. The VOCs were analyzed with a gas chromatography mass spectrometer (GC/MS). GC/MS data show that in ...[more]

PMID: 34308276

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