Sarcopenia and serum biomarkers of oxidative stress after a 6-month physical activity intervention in women with metastatic breast cancer: results from the ABLE feasibility trial.

ABSTRACT:

Purpose

Sarcopenia has been identified as an important prognostic factor for patients with cancer. This study aimed at exploring the potential associations between a 6-month physical activity intervention and muscle characteristics, sarcopenia, oxidative stress and toxicities in patients with metastatic breast cancer.

Methods

Women newly diagnosed with metastatic breast cancer (N = 49) participated in an unsupervised, personalized, 6-month physical activity intervention with activity tracker. Computerized tomography images at the third lumbar vertebra were analysed at baseline, three months and six months to assess sarcopenia (muscle mass index < 40 cm²/m²) and muscle quality (poor if muscle attenuation < 37.8 Hounsfield Units). Oxidative markers includ

SUBMITTER: Delrieu L 

PROVIDER: S-EPMC8272711 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature