Pulmonary and intestinal microbiota dynamics during Gram-negative pneumonia-derived sepsis.

ABSTRACT:

Background

The gut microbiome plays a protective role in the host defense against pneumonia. The composition of the lung microbiota has been shown to be predictive of clinical outcome in critically ill patients. However, the dynamics of the lung and gut microbiota composition over time during severe pneumonia remains ill defined. We used a mouse model of pneumonia-derived sepsis caused by Klebsiella pneumoniae in order to follow the pathogen burden as well as the composition of the lung, tongue and fecal microbiota from local infection towards systemic spread.

Results

Already at 6 h post-inoculation with K. pneumoniae, marked changes in the lung microbiota were seen. The alpha diversity of the lung microbiota did not change throughout the infection, whereas the beta diversit

SUBMITTER: Wolff NS 

PROVIDER: S-EPMC8272965 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature