Optimizing reconstruction parameters for quantitative ¹²⁴I-PET in the presence of therapeutic doses of ¹³¹I.

ABSTRACT:

Background

The goal of this work was to determine the quantitative accuracy and optimal reconstruction parameters for ¹²⁴I-PET imaging in the presence of therapeutic levels of ¹³¹I. In this effort, images were acquired on a GE D710 PET/CT scanner using a NEMA IEC phantom with spheres containing ¹²⁴I and increasing amounts of ¹³¹I activity in the background. At each activity level, two scans were acquired, one with the phantom centered in the field of view (FOV) and one 11.2 cm off-center. Reconstructions used an ordered subset expectation maximization algorithm with up to 100 iterations of 16 subsets, with and without time-of-flight (TOF) information. Results were evaluated visually and by comparing the ¹²⁴I activity relative t

SUBMITTER: Fanchon LM 

PROVIDER: S-EPMC8273044 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature