The nasal microbiome, nasal transcriptome, and pet sensitization.

ABSTRACT:

Background

Pet allergies are common in children with asthma. Microbiota and host responses may mediate allergen sensitization.

Objective

We sought to uncover host-microbe relationships in pet allergen sensitization via joint examination of the nasal microbiome and nasal transcriptome.

Methods

We collected nasal samples from 132 children with asthma for parallel 16S rRNA and RNA sequencing. Specific IgE levels for cat and dog dander were measured. Analyses of the nasal microbiome, nasal transcriptome, and their correlations were performed with respect to pet sensitization status.

Results

Among the 132 children, 91 (68.9%) were cat sensitized and 96 (72.7%) were dog sensitized. Cat sensitization was associated with lower nasal microbial diversity by Shannon index

SUBMITTER: Chun Y 

PROVIDER: S-EPMC8273076 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature