Small whole heart volume predicts cardiovascular events in patients with stable chest pain: insights from the PROMISE trial.

ABSTRACT:

Objectives

The size of the heart may predict major cardiovascular events (MACE) in patients with stable chest pain. We aimed to evaluate the prognostic value of 3D whole heart volume (WHV) derived from non-contrast cardiac computed tomography (CT).

Methods

Among participants randomized to the CT arm of the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE), we used deep learning to extract WHV, defined as the volume of the pericardial sac. We compared the WHV across categories of cardiovascular risk factors and coronary artery disease (CAD) characteristics and determined the association of WHV with MACE (all-cause death, myocardial infarction, unstable angina; median follow-up: 26 months).

Results

In the 3798 included patients (60.5 ± 8.2 yea

SUBMITTER: Foldyna B 

PROVIDER: S-EPMC8273107 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature