Mapping Disease Course Across the Mood Disorder Spectrum Through a Research Domain Criteria Framework.

ABSTRACT:

Background

The National Institute of Mental Health Research Domain Criteria (RDoC) initiative aims to establish a neurobiologically valid framework for classifying mental illness. Here, we examined whether the RDoC construct of reward learning and three aspects of its underlying neurocircuitry predicted symptom trajectories in individuals with mood pathology.

Methods

Aligning with the RDoC approach, we recruited individuals (n = 80 with mood disorders [58 unipolar and 22 bipolar] and n = 32 control subjects; 63.4% female) based on their performance on a laboratory-based reward learning task rather than clinical diagnosis. We then assessed 1) anterior cingulate cortex prediction errors using electroencephalography, 2) striatal reward prediction errors using functional magneti

SUBMITTER: Whitton AE 

PROVIDER: S-EPMC8273113 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature