Resolving cellular and molecular diversity along the hippocampal anterior-to-posterior axis in humans.

ABSTRACT: The hippocampus supports many facets of cognition, including learning, memory, and emotional processing. Anatomically, the hippocampus runs along a longitudinal axis, posterior to anterior in primates. The structure, function, and connectivity of the hippocampus vary along this axis. In human hippocampus, longitudinal functional heterogeneity remains an active area of investigation, and structural heterogeneity has not been described. To understand the cellular and molecular diversity along the hippocampal long axis in human brain and define molecular signatures corresponding to functional domains, we performed single-nuclei RNA sequencing on surgically resected human anterior and posterior hippocampus from epilepsy patients, identifying differentially expressed genes at cellular resolutio

SUBMITTER: Ayhan F 

PROVIDER: S-EPMC8273123 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature