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Cyclic Dipeptides Formation From Linear Dipeptides Under Potentially Prebiotic Earth Conditions.

ABSTRACT: Cyclic dipeptides (DKPs) are peptide precursors and chiral catalysts in the prebiotic process. This study reports proline-containing DKPs that were spontaneously obtained from linear dipeptides under an aqueous solution. Significantly, the yields of DKPs were affected by the sequence of linear dipeptides and whether the reaction contains trimetaphosphate. These findings provide the possibility that DKPs might play a key role in the origin of life.

SUBMITTER: Guo Y

PROVIDER: S-EPMC8273163 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Cyclic Dipeptides Formation From Linear Dipeptides Under Potentially Prebiotic Earth Conditions.

Guo Yeting Y Ying Jianxi J Sun Dongru D Zhang Yumeng Y Zheng Minyang M Ding Ruiwen R Liu Yan Y Zhao Yufen Y

Frontiers in chemistry 20210628

Cyclic dipeptides (DKPs) are peptide precursors and chiral catalysts in the prebiotic process. This study reports proline-containing DKPs that were spontaneously obtained from linear dipeptides under an aqueous solution. Significantly, the yields of DKPs were affected by the sequence of linear dipeptides and whether the reaction contains trimetaphosphate. These findings provide the possibility that DKPs might play a key role in the origin of life. ...[more]

PMID: 34262893

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