Neural changes in youth at high risk for bipolar disorder undergoing family-focused therapy or psychoeducation.

ABSTRACT:

Background

Patients with mood disorders may benefit from psychosocial interventions through changes in brain networks underlying emotion processing. In this study, we used functional magnetic resonance imaging (fMRI) to investigate treatment-related changes in emotion processing networks in youth at familial high risk for bipolar disorder (BD).

Methods

Youth, ages 9-17, were randomly assigned to family-focused therapy for high-risk youth (FFT-HR) or an active comparison treatment, Enhanced Care (EC). Before and after these 4-month treatments, participants underwent fMRI while viewing happy, fearful, and calm facial expressions. Twenty youth in FFT-HR and 20 in EC were included in analyses of pre- to post-treatment changes in activation across the whole brain. Significant clu

SUBMITTER: Garrett AS 

PROVIDER: S-EPMC8273209 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature