The tweety Gene Family: From Embryo to Disease.

ABSTRACT: The tweety genes encode gated chloride channels that are found in animals, plants, and even simple eukaryotes, signifying their deep evolutionary origin. In vertebrates, the tweety gene family is highly conserved and consists of three members-ttyh1, ttyh2, and ttyh3-that are important for the regulation of cell volume. While research has elucidated potential physiological functions of ttyh1 in neural stem cell maintenance, proliferation, and filopodia formation during neural development, the roles of ttyh2 and ttyh3 are less characterized, though their expression patterns during embryonic and fetal development suggest potential roles in the development of a wide range of tissues including a role in the immune system in response to pathogen-a

SUBMITTER: Nalamalapu RR 

PROVIDER: S-EPMC8273234 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature