Identification of Gene Loci That Overlap Between Mental Disorders and Poor Prognosis of Cancers.

ABSTRACT: Background: Co-morbid psychiatric disorders are common in patients with cancers, which make the treatment more difficult. Studying the connection between mental disease-related genes and the prognosis of cancers may potentially lead to novel therapeutic methods. Method: All mental disorders genes were selected from published articles. The correlations between the expression of these genes and the prognosis of different cancers were analyzed by starBase v2.0 and TIMER. The molecular functions, reactome pathways, and interactions among diverse genes were explored via the STRING tool. Results: 239 genes were identified for further survival analysis, 5 of which were overlapping genes across at least five cancer types, including RHEBL1, PDE4B, ANKRD55, EPHB2, and GIMAP7. 14

SUBMITTER: Xu JL 

PROVIDER: S-EPMC8273260 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature