Investigating Different DNA Methylation Patterns at the Resolution of Methylation Haplotypes.

ABSTRACT: Different DNA methylation patterns presented on different tissues or cell types are considered as one of the main reasons accounting for the tissue-specific gene expressions. In recent years, many methods have been proposed to identify differentially methylated regions (DMRs) based on the mixture of methylation signals from homologous chromosomes. To investigate the possible influence of homologous chromosomes on methylation analysis, this paper proposed a method (MHap) to construct methylation haplotypes for homologous chromosomes in CpG dense regions. Through comparing the methylation consistency between homologous chromosomes in different cell types, it can be found that majority of paired methylation haplotypes derived from homologous chromosomes are consistent, while a lower methylati

SUBMITTER: Peng X 

PROVIDER: S-EPMC8273290 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature