Optimal Fluence and Duration of Low-Level Laser Therapy for Efficient Wound Healing in Mice.

ABSTRACT:

Background

Low-level laser (light) therapy is a promising technology that stimulates healing, relieves pain and inflammation, and restores function in injured body parts. However, few studies have compared the effects of light-emitting diodes of different fluence levels or different treatment durations.

Objective

Here, we investigated the effects of various fluence levels and treatment durations on wound closure in mice.

Methods

Full-thickness wounds were created on the dorsal skin using an 8-mm diameter punch, and the wounds were irradiated at 1, 4, or 40 J/cm² for 5 consecutive days starting on day 1. To determine the optimal irradiation duration, wounds were irradiated at the most potent fluence of previous study for 5, 10, or 15 days. Photographic docum

SUBMITTER: Yoon J 

PROVIDER: S-EPMC8273318 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature