Unknown

Dataset Information

0

Immunomodulation with IL-17 and TNF-α in spondyloarthritis: focus on the eye and the central nervous system.


ABSTRACT: Tumor necrosis factor alpha (TNF-α) and interleukin-17 (IL-17) are two pro-inflammatory cytokines involved in the pathophysiology of spondyloarthritis (SpA). Therapies targeting TNF-α or IL-17 are used as a second line among SpA patients failing non-steroidal anti-inflammatory drugs. The choice of such treatment has to take into account the patient's comorbidities. Neurologic diseases are common and their association with SpA deserves to be studied. Therefore, the role of TNF-α and IL-17 cytokines is worth investigating in these neuropsychiatric diseases. This review aimed to explore the role of TNF-α and IL-17 in the pathogenesis of uveitis, multiple sclerosis, neuromyelitis optica, Alzheimer's disease, Parkinson's disease and depression. This update is critical to guide the therapeutic management of these co-morbidities in SpA patients.

SUBMITTER: How Shing Koy E 

PROVIDER: S-EPMC8273400 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

altmetric image

Publications

Immunomodulation with IL-17 and TNF-α in spondyloarthritis: focus on the eye and the central nervous system.

How Shing Koy Elsa E   Labauge Pierre P   Baillet Athan A   Prati Clément C   Marotte Hubert H   Pers Yves-Marie YM  

Therapeutic advances in musculoskeletal disease 20210709


Tumor necrosis factor alpha (TNF-α) and interleukin-17 (IL-17) are two pro-inflammatory cytokines involved in the pathophysiology of spondyloarthritis (SpA). Therapies targeting TNF-α or IL-17 are used as a second line among SpA patients failing non-steroidal anti-inflammatory drugs. The choice of such treatment has to take into account the patient's comorbidities. Neurologic diseases are common and their association with SpA deserves to be studied. Therefore, the role of TNF-α and IL-17 cytokin  ...[more]

Similar Datasets

| S-EPMC10572174 | biostudies-literature
| S-EPMC2858152 | biostudies-literature
| S-EPMC3048151 | biostudies-literature
| S-EPMC2800821 | biostudies-literature
| S-EPMC5376972 | biostudies-literature
| S-EPMC8104974 | biostudies-literature
2010-03-07 | E-GEOD-19272 | biostudies-arrayexpress
| S-EPMC7504446 | biostudies-literature
2010-03-01 | GSE19272 | GEO
| S-EPMC4519128 | biostudies-literature