Immunomodulation with IL-17 and TNF-α in spondyloarthritis: focus on the eye and the central nervous system.
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ABSTRACT:
SUBMITTER: How Shing Koy E
PROVIDER: S-EPMC8273400 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Immunomodulation with IL-17 and TNF-α in spondyloarthritis: focus on the eye and the central nervous system.
How Shing Koy Elsa E Labauge Pierre P Baillet Athan A Prati Clément C Marotte Hubert H Pers Yves-Marie YM
Therapeutic advances in musculoskeletal disease 20210709
Tumor necrosis factor alpha (TNF-α) and interleukin-17 (IL-17) are two pro-inflammatory cytokines involved in the pathophysiology of spondyloarthritis (SpA). Therapies targeting TNF-α or IL-17 are used as a second line among SpA patients failing non-steroidal anti-inflammatory drugs. The choice of such treatment has to take into account the patient's comorbidities. Neurologic diseases are common and their association with SpA deserves to be studied. Therefore, the role of TNF-α and IL-17 cytokin ...[more]
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