Effect of Cytochrome P450 Family 2 Subfamily R Member 1 Variants on the Predisposition of Coronary Heart Disease in the Chinese Han Population.

ABSTRACT: Propose: Cytochrome P450 family 2 subfamily R member 1 (CYP2R1) variations can affect the activity of 25-hydroxylase, resulting in the deficiency of 25(OH)D, which leads to an increased incidence and mortality of coronary heart disease (CHD). The purpose is to assess the influence of CYP2R1 variants on CHD risk among the Chinese Han population. Methods: A total of 508 CHD patients and 510 healthy controls were enrolled. The MassARRAY platform completed genotyping of CYP2R1 variants. Odds ratios (ORs) with 95% confidence intervals (CI) were calculated using logistic regression analysis. Results: Rs6486205 (OR = 1.25, 95% CI: 1.05-1.50, p = 0.014), rs10741657 (OR = 1.29, 95% CI: 1.08-1.54, p = 0.005), and rs2060793 (OR = 1.27, 95% CI: 1.06-1.5

SUBMITTER: Wang Q 

PROVIDER: S-EPMC8273490 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature