Whole-Genome Methylation Study of Congenital Lung Malformations in Children.

ABSTRACT:

Background and objectives

The treatment of asymptomatic patients with congenital pulmonary malformations (CPMs) remains controversial, partially because the relationship between congenital lung malformations and malignancy is still undefined. Change in methylation pattern is a crucial event in human cancer, including lung cancer. We therefore studied all differentially methylated regions (DMRs) in a series of CPMs in an attempt to find methylation anomalies in genes already described in association with malignancy.

Methods

The DNA extracted from resected congenital lung malformations and control lung tissue was screened using Illumina MethylationEPIC arrays. Comparisons between the group of malformed samples or the malformed samples of same histology or each malformed sample

SUBMITTER: Patrizi S 

PROVIDER: S-EPMC8273538 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature