Ontology highlight
ABSTRACT:
SUBMITTER: Cheng YW
PROVIDER: S-EPMC8273546 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Cheng Yu-Wen YW Zhang Ze-Bei ZB Lan Bei-Di BD Lan Bei-Di BD Lin Jing-Rong JR Chen Xiao-Hui XH Kong Ling-Ran LR Xu Lian L Ruan Cheng-Chao CC Gao Ping-Jin PJ
The Journal of experimental medicine 20210708 9
Obesity-induced secretory disorder of adipose tissue-derived factors is important for cardiac damage. However, whether platelet-derived growth factor-D (PDGF-D), a newly identified adipokine, regulates cardiac remodeling in angiotensin II (AngII)-infused obese mice is unclear. Here, we found obesity induced PDGF-D expression in adipose tissue as well as more severe cardiac remodeling compared with control lean mice after AngII infusion. Adipocyte-specific PDGF-D knockout attenuated hypertensive ...[more]