LYG1 Deficiency Attenuates the Severity of Acute Graft-Versus-Host Disease via Skewing Allogeneic T Cells Polarization Towards Treg Cells.

ABSTRACT: Acute graft-versus-host disease (aGVHD) is a lethal complication after allogeneic hematopoietic stem cell transplantation. The mechanism involves the recognition of host antigens by donor-derived T cells which induces augmented response of alloreactive T cells. In this study, we characterized the role of a previously identified novel classical secretory protein with antitumor function-LYG1 (Lysozyme G-like 1), in aGVHD. LYG1 deficiency reduced the activation of CD4⁺ T cells and Th1 ratio, but increased Treg ratio in vitro by MLR assay. By using major MHC mismatched aGVHD model, LYG1 deficiency in donor T cells or CD4⁺ T cells attenuated aGVHD severity, inhibited CD4⁺ T cells activation and IFN-γ expression, promoted FoxP3 expression, suppressed CXCL9

SUBMITTER: Liu H 

PROVIDER: S-EPMC8273552 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature