A Novel HAGE/WT1-ImmunoBody^® Vaccine Combination Enhances Anti-Tumour Responses When Compared to Either Vaccine Alone.

ABSTRACT: Many cancers, including myeloid leukaemia express the cancer testis antigen (CTA) DDX43 (HAGE) and/or the oncogene Wilms' tumour (WT1). Here we demonstrate that HAGE/WT1-ImmunoBody^® vaccines derived T-cells can kill ex-vivo human CML cell lines expressing these antigens and significantly delay B16/HHDII⁺/DR1⁺/HAGE⁺/WT1⁺ tumour growth in the HHDII/DR1 mice and prolonged mouse survival in the prophylactic setting in comparison to non-immunised control mice. We show that immunisation of HHDII/DR1 mice with HAGE- and WT1-ImmunoBody^® DNA vaccines in a prime-boost regime in two different flanks induce significant IFN-γ release by splenocytes from treated mice, and a significant level of cytotoxicity against tumour targets e

SUBMITTER: Almshayakhchi R 

PROVIDER: S-EPMC8273701 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature