Salivary Heme Oxygenase-1: A Potential Biomarker for Central Neurodegeneration.

ABSTRACT:

Background

Parkinson disease (PD) is the second most common neurodegenerative disease, affecting 2% of the population over 65 years of age. PD diagnosis is based on clinical examination and can only be confirmed during autopsy. In 2018, we reported that heme oxygenase-1 (HO-1), an inducible stress response protein important for heme catabolism and implicated in PD pathology, was higher in PD saliva relative to healthy controls, suggesting that salivary HO-1 may serve as a potential biomarker of PD.

Objectives

To ascertain whether HO-1 protein levels are elevated in PD saliva relative to degenerative neurological, non-degenerative neurological and healthy controls.

Methodology

The study included 307 participants comprising 75 participants with idiopathic PD and 3 contr

SUBMITTER: Galindez JM 

PROVIDER: S-EPMC8273869 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature