Ontology highlight
ABSTRACT:
SUBMITTER: Hu Z
PROVIDER: S-EPMC8273876 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Hu Zhuting Z Leet Donna E DE Allesøe Rosa L RL Oliveira Giacomo G Li Shuqiang S Luoma Adrienne M AM Liu Jinyan J Forman Juliet J Huang Teddy T Iorgulescu J Bryan JB Holden Rebecca R Sarkizova Siranush S Gohil Satyen H SH Redd Robert A RA Sun Jing J Elagina Liudmila L Giobbie-Hurder Anita A Zhang Wandi W Peter Lauren L Ciantra Zoe Z Rodig Scott S Olive Oriol O Shetty Keerthi K Pyrdol Jason J Uduman Mohamed M Lee Patrick C PC Bachireddy Pavan P Buchbinder Elizabeth I EI Yoon Charles H CH Neuberg Donna D Pentelute Bradley L BL Hacohen Nir N Livak Kenneth J KJ Shukla Sachet A SA Olsen Lars Rønn LR Barouch Dan H DH Wucherpfennig Kai W KW Fritsch Edward F EF Keskin Derin B DB Wu Catherine J CJ Ott Patrick A PA
Nature medicine 20210121 3
Personal neoantigen vaccines have been envisioned as an effective approach to induce, amplify and diversify antitumor T cell responses. To define the long-term effects of such a vaccine, we evaluated the clinical outcome and circulating immune responses of eight patients with surgically resected stage IIIB/C or IVM1a/b melanoma, at a median of almost 4 years after treatment with NeoVax, a long-peptide vaccine targeting up to 20 personal neoantigens per patient ( NCT01970358 ). All patients were ...[more]