Screening and Preparation of Cocrystals: A Comparative Study of Mechanochemistry vs Slurry Methods.

ABSTRACT: Cocrystals of biologically active molecular compounds have potential utility in drug products thanks to their effect upon physicochemical properties such as aqueous solubility. The fact that control of cocrystallization can be more challenging than crystallization of single-component crystals means that systematic studies that address the methodology of cocrystal screening, production, and purification are a topical subject. We previously reported a comparison of slow evaporation vs mechanochemistry for a library of 25 molecular cocrystals. Herein, we compare the previously reported mechanochemistry results (solvent-drop grinding (SDG) with eight solvents) with new results obtained from slurrying in five preferred solvents using the same library of 25 cocrystals. Overall, both methods were

SUBMITTER: Haskins MM 

PROVIDER: S-EPMC8273892 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature