Individualized resuscitation strategy for septic shock formalized by finite mixture modeling and dynamic treatment regimen.

ABSTRACT:

Background

Septic shock comprises a heterogeneous population, and individualized resuscitation strategy is of vital importance. The study aimed to identify subclasses of septic shock with non-supervised learning algorithms, so as to tailor resuscitation strategy for each class.

Methods

Patients with septic shock in 25 tertiary care teaching hospitals in China from January 2016 to December 2017 were enrolled in the study. Clinical and laboratory variables were collected on days 0, 1, 2, 3 and 7 after ICU admission. Subclasses of septic shock were identified by both finite mixture modeling and K-means clustering. Individualized fluid volume and norepinephrine dose were estimated using dynamic treatment regime (DTR) model to optimize the final mortality outcome. DTR models were

SUBMITTER: Ma P 

PROVIDER: S-EPMC8273991 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature