Characterization of TGFβ-associated molecular features and drug responses in gastrointestinal adenocarcinoma.

ABSTRACT:

Background

Gastrointestinal adenocarcinoma (GIAD) has caused a serious disease burden globally. Targeted therapy for the transforming growth factor beta (TGF-β) signaling pathway is becoming a reality. However, the molecular characterization of TGF-β associated signatures in GIAD requires further exploration.

Methods

Multi-omics data were collected from TCGA and GEO database. A pivotal unsupervised clustering for TGF-β level was performed by distinguish status of TGF-β associated genes. We analyzed differential mRNAs, miRNAs, proteins gene mutations and copy number variations in both clusters for comparison. Enrichment of pathways and gene sets were identified in each type of GIAD. Then we performed differential mRNA related drug response by collecting data from GDSC. At las

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC8274021 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature