Sustained zinc release in cooperation with CaP scaffold promoted bone regeneration via directing stem cell fate and triggering a pro-healing immune stimuli.

ABSTRACT: Metal ions have been identified as important bone metabolism regulators and widely used in the field of bone tissue engineering, however their exact role during bone regeneration remains unclear. Herein, the aim of study was to comprehensively explore the interactions between osteoinductive and osteo-immunomodulatory properties of these metal ions. In particular, the osteoinductive role of zinc ions (Zn²⁺), as well as its interactions with local immune microenvironment during bone healing process, was investigated in this study using a sustained Zn²⁺ delivery system incorporating Zn²⁺ into β-tricalcium phosphate/poly(L-lactic acid) (TCP/PLLA) scaffolds. The presence of Zn²⁺ largely enhanced osteogenic differentiation of periosteum-derived progeni

SUBMITTER: Huang X 

PROVIDER: S-EPMC8274038 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature