NT157 Inhibits HCC Migration via Downregulating the STAT3/Jab1 Signaling Pathway.

ABSTRACT:

Purpose

The high fatality-to-case ratio of hepatocellular carcinoma is directly related to metastasis. The signal transducer and activator of transcription-3 is a key mediator of the cytokine and growth factor signaling pathways and drives the transcription of genes responsible for cancer-associated phenotypes. However, so far, no specific inhibitor for signal transducer and activator of transcription-3 has been used in clinical practice. Therefore, targeting the signal transducer and activator of transcription-3 for cancer therapy is highly desired to improve outcomes in patients with hepatocellular carcinoma.

Experimental design

Using the small-molecule inhibitor NT157, the effect of signal transducer and activator of transcription-3 inhibition on cell migration was tested

SUBMITTER: Yu S 

PROVIDER: S-EPMC8274079 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature