Systematic review and Meta-Analysis of Mendelian randomisation analyses of Abdominal aortic aneurysms.

ABSTRACT:

Introduction

Mendelian randomisation (MR) has been suggested to be able to overcome biases of observational studies, but no meta-analysis is available on MR studies on abdominal aortic aneurysm (AAA). This systematic review and Meta-analysis examined the evidence of causal risk factors for AAA identified in MR studies.

Methods

Publicly available databases were systematically searched for MR studies that reported any causal risk factors for AAA diagnosis. Meta-analyses were performed using random effect models and reported as odds ratio (OR) and 95% confidence intervals (CI). Study quality was assessed using a modified version of Strengthening the Reporting of Mendelian Randomisation Studies (STROBE-MR) guidelines.

Results

Sixteen MR studies involving 34,050 patients w

SUBMITTER: Ibrahim M 

PROVIDER: S-EPMC8274287 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature