A systematic review and network meta-analysis of interventions for subjective cognitive decline.

ABSTRACT:

Background

Subjective cognitive decline (SCD) is considered a risk factor for Alzheimer's disease (AD), highlighting the need for identifying and ranking effective interventions. This was addressed in a systematic review and network meta-analysis (NMA) of pharmacological and non-pharmacological interventions for SCD.

Methods

MEDLINE, Web of Science Core Collection, CENTRAL, and PsycINFO were searched for randomized controlled trials (RCTs) investigating effects on memory, global cognition, and quality of life. Random-effect model NMAs were conducted. The Cochrane Risk-of-Bias-2 tool assessed methodological quality. Prospero-Registration: CRD42020180457.

Results

The systematic review included 56 RCTs. Education programs were most effective for improving memory, second

SUBMITTER: Roheger M 

PROVIDER: S-EPMC8274308 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature