Response heterogeneity to lifestyle intervention among Latino adolescents.

ABSTRACT:

Objective

To characterize the heterogeneity in response to lifestyle intervention among Latino adolescents with obesity.

Methods

We conducted secondary data analysis of 90 Latino adolescents (age 15.4 ± 0.9 y, female 56.7%) with obesity (BMI% 98.1 ± 1.5%) that were enrolled in a 3 month lifestyle intervention and were followed for a year. Covariance pattern mixture models identified response phenotypes defined by changes in insulin sensitivity as measured using a 2 hour oral glucose tolerance test. Baseline characteristics were compared across response phenotypes using one-way ANOVA and chi-square test.

Results

Three distinct response phenotypes (PH1, PH2, PH3) were identified. PH1 exhibited the most robust response defined by the greatest increase in insulin sensitiv

SUBMITTER: Pena A 

PROVIDER: S-EPMC8274397 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature