Mapping T Cell Responses to Native and Neo-Islet Antigen Epitopes in at Risk and Type 1 Diabetes Subjects.

ABSTRACT:

Aims

Recent studies highlight the potentially important role of neoepitopes in breaking immune tolerance in type 1 diabetes. T cell reactivity to these neoepitopes has been reported, but how this response compares quantitatively and phenotypically with previous reports on native epitopes is not known. Thus, an understanding of the relationship between native and neoepitopes and their role as tolerance breakers or disease drivers in type 1 diabetes is required. We set out to compare T cell reactivity and phenotype against a panel of neo- and native islet autoantigenic epitopes to examine how this relates to stages of type 1 diabetes development.

Methods

Fifty-four subjects comprising patients with T1D, and autoantibody-positive unaffected family members were tested against a

SUBMITTER: Arif S 

PROVIDER: S-EPMC8274489 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature