Gender differences in the link between depressive symptoms and ex vivo inflammatory responses are associated with markers of endotoxemia.

ABSTRACT: Depressive symptoms are often linked with higher inflammation and inflammatory responses, although these associations are not always consistent. In a recent study (N=160, 25-65 years, 67% women), our group reported gender differences relevant to this association: In men higher depressive symptoms were related to heightened ex vivo inflammatory responses to lipopolysaccharide (LPS), whereas in women higher depressive symptoms were related to attenuated inflammatory responses. In the present manuscript, we investigate markers of endotoxemia - i.e., markers of the presence of endotoxin in the blood, presumably due to bacterial translocation from the gut - as factors that elicit gender-dependent immune responses that may be associated with links between depressive symptoms and inflammation. We

SUBMITTER: Knight EL 

PROVIDER: S-EPMC8274590 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature