ILRUN Downregulates ACE2 Expression and Blocks Infection of Human Cells by SARS-CoV-2.

ABSTRACT: The human protein-coding gene ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domains; previously C6orf106) was identified as a proviral factor for Hendra virus infection and was recently characterized to function as an inhibitor of type I interferon expression. Here, we have utilized transcriptome sequencing (RNA-seq) to define cellular pathways regulated by ILRUN in the context of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of Caco-2 cells. We find that inhibition of ILRUN expression by RNA interference alters transcription profiles of numerous cellular pathways, including upregulation of the SARS-CoV-2 entry receptor ACE2 and several other members of the renin-angiotensin aldosterone system. In addition, transcripts of the SAR

SUBMITTER: Tribolet L 

PROVIDER: S-EPMC8274604 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature