Inhibition of Antiviral Innate Immunity by Foot-and-Mouth Disease Virus L^pro through Interaction with the N-Terminal Domain of Swine RNase L.

ABSTRACT: Foot-and-mouth disease virus (FMDV) is the pathogen of foot-and-mouth disease (FMD), which is a highly contagious disease in cloven-hoofed animals. To survive in the host, FMDV has evolved multiple strategies to antagonize host innate immune responses. In this study, we showed that the leader protease (L^pro) of FMDV, a papain-like proteinase, promoted viral replication by evading the antiviral interferon response through counteracting the 2',5'-oligoadenylate synthetase (OAS)/RNase L system. Specifically, we observed that the titers of L^pro deletion virus were significantly lower than those of wild-type FMDV (FMDV-WT) in cultured cells. Our mechanistic studies demonstrated that L^pro interfered with the OAS/RNase L pathway by interacting with the N-terminal

SUBMITTER: Sui C 

PROVIDER: S-EPMC8274615 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature