Health Effects of Naphthalene Exposure: A Systematic Evidence Map and Analysis of Potential Considerations for Dose-Response Evaluation.

ABSTRACT:

Background

Naphthalene is a polycyclic aromatic hydrocarbon that has been associated with health effects, including cancer. As the state of the science on naphthalene toxicity continues to evolve, updated toxicity reference value(s) may be required to support human health risk assessment.

Objectives

We present a systematic evidence map of studies that could be used to derive toxicity reference value(s) for naphthalene.

Methods

Human and animal health effect studies and physiologically based pharmacokinetic (PBPK) models were identified from a literature search based on populations, exposures, comparators, and outcomes (PECO) criteria. Human and animal studies meeting PECO criteria were refined to a smaller subset considered most informative for deriving chronic refere

SUBMITTER: Yost EE 

PROVIDER: S-EPMC8274693 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature