Clinical features, biochemistry, and HLA-DRB1 status in youth-onset type 1 diabetes in Sudan.

ABSTRACT:

Objective

To further understand clinical and biochemical features, and HLA-DRB1 genotypes, in new cases of diabetes in Sudanese children and adolescents.

Research design and methods

Demographic characteristics, clinical information, and biochemical parameters (blood glucose, HbA1c, C-peptide, autoantibodies against glutamic acid decarboxylase 65 [GADA] and insulinoma-associated protein-2 [IA-2A], and HLA-DRB1) were assessed in 99 individuals <18 years, recently (<18 months) clinically diagnosed with T1D. HLA-DRB1 genotypes for 56 of these Arab individuals with T1D were compared to a mixed control group of 198 healthy Arab (75%) and African (25%) individuals without T1D.

Results

Mean ± SD age at diagnosis was 10.1 ± 4.3 years (range 0.7-17.6 years) with mode at 9-12 ye

SUBMITTER: Ibrahim TAM 

PROVIDER: S-EPMC8274711 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature