Restoring metabolism of myeloid cells reverses cognitive decline in ageing.

ABSTRACT: Ageing is characterized by the development of persistent pro-inflammatory responses that contribute to atherosclerosis, metabolic syndrome, cancer and frailty^1-3. The ageing brain is also vulnerable to inflammation, as demonstrated by the high prevalence of age-associated cognitive decline and Alzheimer's disease^4-6. Systemically, circulating pro-inflammatory factors can promote cognitive decline^7,8, and in the brain, microglia lose the ability to clear misfolded proteins that are associated with neurodegeneration^9,10. However, the underlying mechanisms that initiate and sustain maladaptive inflammation with ageing are not well defined. Here we show that in ageing mice myeloid cell bioenergetics are suppressed in response to increased signalling

SUBMITTER: Minhas PS 

PROVIDER: S-EPMC8274816 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature