Association of Aldehyde Dehydrogenase 2 Gene Polymorphism with Myocardial Infarction.

ABSTRACT:

Objective

This study explored the correlation between myocardial infarction (MI) and the Glu504Lys polymorphism in the aldehyde dehydrogenase 2 (ALDH2) gene in the Qingyuan area.

Methods

The Glu504Lys polymorphism of the ALDH2 gene was analyzed using the polymerase chain reaction and deoxyribonucleic acid microarray analysis for 468 patients diagnosed with MI for the first time and 132 healthy subjects.

Results

There was a significant difference in the distribution of the ALDH2 genotype between the MI group and the control group (P = 0.0492), but there was no significant difference in allele frequency between the two groups (P = 0.1363). The clinical data showed that there were statistically significant differences (P < 0.05) in the two groups' ge

SUBMITTER: Zhu LP 

PROVIDER: S-EPMC8274824 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature