Impact of assumptions on future costs, disutility and mortality in cost-effectiveness analysis; a model exploration.

ABSTRACT:

Introduction

In cost-effectiveness analyses, the future costs, disutility and mortality from alternative causes of morbidity are often not completely taken into account. We explored the impact of different assumed values for each of these factors on the cost-effectiveness of screening for colorectal cancer (CRC) and esophageal adenocarcinoma (EAC).

Methods

Twenty different CRC screening strategies and two EAC screening strategies were evaluated using microsimulation. Average health-related expenses, disutility and mortality by age for the U.S. general population were estimated using surveys and lifetables. First, we evaluated strategies under default assumptions, with average mortality, and no accounting for health-related costs and disutility. Then, we varied costs, disutil

SUBMITTER: Omidvari AH 

PROVIDER: S-EPMC8274850 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature