Risk of acute myocardial infarction among new users of chondroitin sulfate: A nested case-control study.

ABSTRACT:

Objective

To test the hypothesis that the use of chondroitin sulfate (CS) or glucosamine reduces the risk of acute myocardial infarction (AMI).

Design

Case-control study nested in a primary cohort of patients aged 40 to 99 years, using the database BIFAP during the 2002-2015 study period. From this cohort, we identified incident cases of AMI and randomly selected five controls per case, matched by exact age, gender, and index date. Adjusted odds ratios (AOR) and 95% confidence interval (CI) were computed through a conditional logistic regression. Only new users of CS or glucosamine were considered.

Results

A total of 23,585 incident cases of AMI and 117,405 controls were included. Of them, 89 cases (0.38%) and 757 controls (0.64%) were current users of CS at index dat

SUBMITTER: Mazzucchelli R 

PROVIDER: S-EPMC8274913 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature