Digital twinning of Cellular Capsule Technology: Emerging outcomes from the perspective of porous media mechanics.

ABSTRACT: Spheroids encapsulated within alginate capsules are emerging as suitable in vitro tools to investigate the impact of mechanical forces on tumor growth since the internal tumor pressure can be retrieved from the deformation of the capsule. Here we focus on the particular case of Cellular Capsule Technology (CCT). We show in this contribution that a modeling approach accounting for the triphasic nature of the spheroid (extracellular matrix, tumor cells and interstitial fluid) offers a new perspective of analysis revealing that the pressure retrieved experimentally cannot be interpreted as a direct picture of the pressure sustained by the tumor cells and, as such, cannot therefore be used to quantify the critical pressure which induces stress-induced phenotype switch in tumor cells. The propo

SUBMITTER: Urcun S 

PROVIDER: S-EPMC8274916 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature