Ontology highlight
ABSTRACT:
SUBMITTER: Sladowska M
PROVIDER: S-EPMC8274918 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Sladowska Maria M Turek Michał M Kim Min-Ji MJ Drabikowski Krzysztof K Mussulini Ben Hur Marins BHM Mohanraj Karthik K Serwa Remigiusz A RA Topf Ulrike U Chacinska Agnieszka A
PLoS biology 20210712 7
Defects in mitochondrial function activate compensatory responses in the cell. Mitochondrial stress that is caused by unfolded proteins inside the organelle induces a transcriptional response (termed the "mitochondrial unfolded protein response" [UPRmt]) that is mediated by activating transcription factor associated with stress 1 (ATFS-1). The UPRmt increases mitochondrial protein quality control. Mitochondrial dysfunction frequently causes defects in the import of proteins, resulting in the acc ...[more]