Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans.

ABSTRACT: Defects in mitochondrial function activate compensatory responses in the cell. Mitochondrial stress that is caused by unfolded proteins inside the organelle induces a transcriptional response (termed the "mitochondrial unfolded protein response" [UPRmt]) that is mediated by activating transcription factor associated with stress 1 (ATFS-1). The UPRmt increases mitochondrial protein quality control. Mitochondrial dysfunction frequently causes defects in the import of proteins, resulting in the accumulation of mitochondrial proteins outside the organelle. In yeast, cells respond to mistargeted mitochondrial proteins by increasing activity of the proteasome in the cytosol (termed the "unfolded protein response activated by mistargeting of proteins" [UPRam]). The presence and relevance of this

SUBMITTER: Sladowska M 

PROVIDER: S-EPMC8274918 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature