Relationship between West African ancestry with lung cancer risk and survival in African Americans.

ABSTRACT:

Purpose

African Americans, especially men, have a higher incidence of lung cancer compared with all other racial and ethnic groups in the US. Self-reported race is frequently used in genomic research studies to capture an individual's race or ethnicity. However, it is clear from studies of genetic admixture that human genetic variation does not segregate into the same biologically discrete categories as socially defined categories of race. Previous studies have suggested that the degree of West African ancestry among African Americans can contribute to cancer risk in this population, though few studies have addressed this question in lung cancer.

Methods

Using a genetic ancestry panel of 100 SNPs, we estimated West African, European, and Native American ancestry in 1,407 sel

SUBMITTER: Mitchell KA 

PROVIDER: S-EPMC8274945 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature