Mechanism of Tetrandrine Against Endometrial Cancer Based on Network Pharmacology.

ABSTRACT:

Background

Endometrial cancer (EC) is one of the most common gynaecological malignancies, and its incidence has been rising over the past decade. Tetrandrine, a bisbenzylisoquinoline alkaloid, has been isolated from a vine used in traditional Chinese medicine, Stephania tetrandra. However, the key mechanism of tetrandrine in EC is still unclear.

Purpose

This research was designed to predict the molecular mechanisms of tetrandrine against EC based on network pharmacology and to further verify these predictions by in vitro experiments.

Methods

The potential therapeutic targets of tetrandrine against EC were predicted by using public databases. Afterwards, the protein-protein interaction (PPI) network of the common targets was constructed, and the key gene targets

SUBMITTER: Shang W 

PROVIDER: S-EPMC8275110 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature