Improved inference of tandem domain duplications.

ABSTRACT:

Motivation

Protein domain duplications are a major contributor to the functional diversification of protein families. These duplications can occur one at a time through single domain duplications, or as tandem duplications where several consecutive domains are duplicated together as part of a single evolutionary event. Existing methods for inferring domain-level evolutionary events are based on reconciling domain trees with gene trees. While some formulations consider multiple domain duplications, they do not explicitly model tandem duplications; this leads to inaccurate inference of which domains duplicated together over the course of evolution.

Results

Here, we introduce a reconciliation-based framework that considers the relative positions of domains within extant sequenc

SUBMITTER: Aluru C 

PROVIDER: S-EPMC8275333 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature