PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway.

ABSTRACT:

Background

Hepatic ischemia-reperfusion (IR) injury is one of the severe complications associated with liver surgery and leads to liver dysfunction. PPARγ is always linked with various physiologic pathways, and it can alleviate liver damage in IR injury.

Aim

In this study, we explored the potential mechanism of PPARγ in the pathogenesis of hepatic IR injury by mice model.

Methods

After treated with si-PPARγ or rosiglitazone, mice were subjected to hepatic ischemia-reperfusion. Liver tissue and blood samples were collected to evaluate liver injury and detected relative mRNA and protein expressions.

Results

The expression of PPARγ was increased after reperfusion. And the alleviation of PPARγ aggravated the liver damage in IR; at

SUBMITTER: Wu L 

PROVIDER: S-EPMC8275421 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature