Generation of plasma cells and CD27^-IgD^- B cells during hantavirus infection is associated with distinct pathological findings.

ABSTRACT:

Objective

Human hantavirus infections can cause haemorrhagic fever with renal syndrome (HFRS). The pathogenic mechanisms are not fully understood, nor if they affect the humoral immune system. The objective of this study was to investigate humoral immune responses to hantavirus infection and to correlate them to the typical features of HFRS: thrombocytopenia and transient kidney dysfunction.

Methods

We performed a comprehensive characterisation of longitudinal antiviral B-cell responses of 26 hantavirus patients and combined this with paired clinical data. In addition, we measured extracellular adenosine triphosphate (ATP) and its breakdown products in circulation and performed in vitro stimulations to address its effect on B cells.

Results

We found that thromb

SUBMITTER: Kerkman PF 

PROVIDER: S-EPMC8275445 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature